Effects of induced diabetes and the administration of aminoguanidine in the biomechanical retention of implants: a study in rats.

BACKGROUND AND OBJECTIVE The present study aimed to assess the effects of induced diabetes and the administration of aminoguanidine in the biomechanical retention of implants in rats. MATERIAL AND METHODS Thirty-six rats were randomly divided into six groups: group 1, healthy rats (no aminoguanidine); group 2 and group 3, healthy rats receiving 10 and 20 mg/kg of aminoguanidine daily, respectively; group 4, diabetic rats (no aminoguanidine); and group 5 and group 6, diabetic rats receiving 10 and 20 mg/kg of aminoguanidine daily, respectively. In each rat an implant was inserted in the femur. After 28 d of healing, the rats were killed. The implants were removed by applying a counter-torque, and the maximum force required for the rupture of the bone-implant interface was recorded using an analog torque meter. The data were evaluated using analysis of variance and the Student's t-test. RESULTS In the healthy groups, no statistically significant difference could be observed in the average counter-torque values for implant removal, whereas in the diabetic groups, a daily dose of 20 mg/kg of aminoguanidine raised the counter-torque values to the values found in healthy rats. CONCLUSION The administration of 20 mg/kg of aminoguanidine daily in diabetic rats raised the biomechanical retention of the implants to the level observed in the healthy rat group.